The supervillain Nemesis blows up a building in Tokyo, killing a SWAT team, and later kills a police inspector. In Washington, D.C., the FBI informs metro police Chief Inspector Blake Morrow that Nemesis is targeting him next. Nemesis soon hijacks Air Force One over the District of Columbia, taking the United States president hostage and crashing the plane, killing hundreds.
Nemesis tells the story of Matt Anderson, whose father had committed suicide after Officer Blake Morrow tried to imprison the father for hunting runaway teenagers with his rich friends. Anderson travelled the world to learn the ways of crime, hoping to fulfil his mother’s dying wish to have Morrow killed.
Nemesis kills twenty-thousand people at the Pentagon using poison gas, allowing Morrow and his aide de camp Stuart to survive in order to taunt Morrow about the inspector’s projected March 12 death. Local police eventually capture Nemesis, who claims he allowed himself to be caught. Nemesis breaks out of prison, killing scores of guards and freeing the inmates, and then blowing it up. He kidnaps Morrow’s children, forcing Morrow to reveal family secrets: his wife had an affair; his son is gay; and his daughter had a secret abortion. Nemesis releases the children but Morrow’s daughter has been impregnated by his son, with her womb rigged to collapse if an abortion is attempted, preventing her from ever again having children. An enraged Morrow eventually believes he has discovered Nemesis’ hideout, and arrives there with a police team only to find it is a trap. The house explodes, knocking Morrow unconscious. When Morrow awakens, a taunting Nemesis reveals that Stuart has been working for Nemesis for the past eight years. Nemesis kills Stuart, and tells Morrow that his “Matthew Anderson” story was made up: He is simply rich and bored, creating death and havoc for his own amusement.
Nemesis then reveals they are in the White House’s Oval Office, where Morrow’s wife Peggy and the U.S. president have bombs strapped to their chests. The staff and Secret Service agents have all been killed, and Nemesis gives Morrow a detonator and tells him he has thirty seconds to kill either the president or his wife. With four seconds left, the president steps-up to Nemesis and tells Morrow to detonate his bomb. Nemesis survives the blast, and in a final confrontation, he and Morrow each shoot each other. Morrow kills Nemesis with a head shot, and himself is taken to emergency surgery. He flatlines during surgery but survives, and as the series concludes is on a beach vacation with his family, including his newborn triplet granddaughters. There he is given a letter, ostensibly given to the waiter ten years earlier, congratulating Morrow and claiming to be from the head of a company that arranges for rich people to become supervillains.