Francis Crick confessed that he was tripping the first time he envisioned the double helix. Steve Jobs called LSD “one of the two or three most important things” he’d experienced. And Bill Wilson claimed it helped to facilitate breakthroughs of a more soulful variety: Decades after co-founding Alcoholics Anonymous, he tried LSD, said it tuned him in to the same spiritual awareness that made sobriety possible, and pitched its therapeutic use—unsuccessfully—to the AA board.